No, large Morphe 35 palettes will not fit in the mesh pocket. However, if you don't have any tall products sticking out of the main compartment, you'll be able to fit 1 laying flat down.

For personal use, unless you have a large makeup collection and looking to travel with a full kit and toiletries, we always recommend the Medium size. The Large size is usually used by professional artists. We highly recommend looking at the dimensions closely.